CMap Candidate Details

Structure:
CMap ID: C10270
Pert ID: BRD-K24844714
Compound Name: fluorouracil
Targets: DPYD; TYMS
MoA: RNA synthesis inhibitor; Thymidylate synthase inhibitor
SMILES: Fc1c[nH]c(=O)[nH]c1=O
InchiKey: GHASVSINZRGABV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90770 BRD-K24844714 HPTEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91347 BRD-K24844714 HUH7 25 uM 72 h 0.0 0.0 0.0 0.4 1.43 2.2
95627 BRD-K24844714 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96326 BRD-K24844714 A375 10 uM 24 h -0.28 -1.16 0.46 -0.53 -1.78 15.65
117055 BRD-K24844714 A549 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
117137 BRD-K24844714 HCC515 3.33 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.03
117182 BRD-K24844714 HEPG2 10 uM 24 h -0.22 -0.91 0.06 0.0 0.0 0.0
120913 BRD-K24844714 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
120960 BRD-K24844714 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120988 BRD-K24844714 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121048 BRD-K24844714 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121116 BRD-K24844714 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
129194 BRD-K24844714 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
129221 BRD-K24844714 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).