CMap Candidate Details

Structure:
CMap ID: C10275
Pert ID: BRD-K24859147
Compound Name: KIN001-242
Targets: RPS6KA3
MoA: Protein kinase inhibitor
SMILES: COCCNCCCn1c(C(=O)CF)c(-c2ccc(C)cc2)c2c(N)ncnc12
InchiKey: UPTQGXMIZXGVSC-UHFFFAOYSA-N
Compound Aliases: KIN-001-242

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33789 BRD-K24859147 A549 10 uM 24 h 0.0 0.0 0.0 0.42 1.48 2.25
34334 BRD-K24859147 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.43
34854 BRD-K24859147 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35551 BRD-K24859147 NEU 10 uM 24 h -0.17 -0.69 0.0 0.0 0.0 0.0
36229 BRD-K24859147 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36523 BRD-K24859147 SKB 10 uM 24 h 0.2 0.84 0.0 0.35 1.25 1.29
36792 BRD-K24859147 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
91539 BRD-K24859147 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91572 BRD-K24859147 HS578T 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91647 BRD-K24859147 MCF??7.00 10 uM 24 h 0.24 1.01 0.12 -0.37 -1.26 1.35
91685 BRD-K24859147 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
91770 BRD-K24859147 SKBR3 2.22 uM 6 h -0.28 -1.17 0.49 0.0 0.0 0.0
94407 BRD-K24859147 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94471 BRD-K24859147 ASC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
94534 BRD-K24859147 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94587 BRD-K24859147 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94627 BRD-K24859147 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94679 BRD-K24859147 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94728 BRD-K24859147 HME1 0.37 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
94782 BRD-K24859147 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94823 BRD-K24859147 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94875 BRD-K24859147 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94925 BRD-K24859147 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95068 BRD-K24859147 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
95109 BRD-K24859147 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95147 BRD-K24859147 SHSY5Y 0.04 uM 24 h 0.28 1.15 0.34 -0.29 -0.97 0.44
95229 BRD-K24859147 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95260 BRD-K24859147 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).