CMap Candidate Details

Structure:
CMap ID: C10407
Pert ID: BRD-K25311561
Compound Name: KU-55933
Targets: ATM
MoA: ATM kinase inhibitor
SMILES: O=c1cc(oc(c1)-c1cccc2Sc3ccccc3Sc12)N1CCOCC1
InchiKey: XRKYMMUGXMWDAO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33720 BRD-K25311561 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36231 BRD-K25311561 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36525 BRD-K25311561 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36794 BRD-K25311561 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90824 BRD-K25311561 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
91540 BRD-K25311561 BT20 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91602 BRD-K25311561 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91686 BRD-K25311561 MDAMB231 10 uM 24 h 0.2 0.82 0.0 -0.33 -1.11 0.9
91754 BRD-K25311561 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
93636 BRD-K25311561 ASC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
93693 BRD-K25311561 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93819 BRD-K25311561 HEK293 0.04 uM 24 h -0.27 -1.11 0.37 0.0 0.0 0.0
93870 BRD-K25311561 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93910 BRD-K25311561 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
93979 BRD-K25311561 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.42 2.76
94006 BRD-K25311561 JURKAT 0.37 uM 24 h 0.29 1.2 0.44 -0.42 -1.42 2.02
94086 BRD-K25311561 NEU 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94185 BRD-K25311561 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94216 BRD-K25311561 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94269 BRD-K25311561 SKL 0.04 uM 24 h 0.21 0.86 0.01 -0.25 -0.83 0.16
94319 BRD-K25311561 THP1 10 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
94364 BRD-K25311561 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95806 BRD-K25311561 NPC 10 uM 6 h 0.0 0.0 0.0 0.38 1.35 1.72
117692 BRD-K25311561 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117738 BRD-K25311561 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117785 BRD-K25311561 HCC515 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
117887 BRD-K25311561 HT29 10 uM 24 h -0.24 -1.01 0.17 0.0 0.0 0.0
117935 BRD-K25311561 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.03 0.62
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).