CMap Candidate Details

Structure:
CMap ID: C10414
Pert ID: BRD-K25325018
Compound Name: GSK-690693
Targets: AKT3; AKT1; AKT2; PRKCQ
MoA: Akt inhibitor
SMILES: CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N
InchiKey: KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
115237 BRD-K25325018 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115284 BRD-K25325018 A549 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
115331 BRD-K25325018 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115379 BRD-K25325018 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115431 BRD-K25325018 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
115481 BRD-K25325018 HT29 10 uM 24 h -0.19 -0.78 0.0 -0.3 -1.02 0.62
115532 BRD-K25325018 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
115581 BRD-K25325018 PC3 3.33 uM 24 h 0.26 1.09 0.22 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).