CMap Candidate Details

Structure:
CMap ID: C10419
Pert ID: BRD-K25340465
Compound Name: OSI-930
Targets: KDR; KIT
MoA: KIT inhibitor; VEGFR inhibitor
SMILES: FC(F)(F)Oc1ccc(NC(=O)c2sccc2NCc2ccnc3ccccc23)cc1
InchiKey: FGTCROZDHDSNIO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91798 BRD-K25340465 HS578T 0.08 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.76
91876 BRD-K25340465 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91959 BRD-K25340465 SKBR3 0.08 uM 6 h -0.24 -0.99 0.13 -0.34 -1.16 1.11
92864 BRD-K25340465 A375 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
92891 BRD-K25340465 A549 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.17
92922 BRD-K25340465 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92984 BRD-K25340465 CD34 0.04 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.34
93036 BRD-K25340465 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93074 BRD-K25340465 HEK293 0.04 uM 24 h 0.29 1.22 0.48 0.28 0.98 0.36
93120 BRD-K25340465 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93161 BRD-K25340465 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93210 BRD-K25340465 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93267 BRD-K25340465 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
93308 BRD-K25340465 MCF10A 3.33 uM 24 h -0.22 -0.9 0.04 -0.26 -0.88 0.25
93350 BRD-K25340465 MDAMB231 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93412 BRD-K25340465 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93441 BRD-K25340465 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93475 BRD-K25340465 SKL 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.74
93536 BRD-K25340465 THP1 3.33 uM 24 h 0.22 0.93 0.05 0.25 0.88 0.19
93577 BRD-K25340465 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).