CMap Candidate Details

Structure:
CMap ID: C10448
Pert ID: BRD-K25433859
Compound Name: maprotiline
Targets: SLC6A2
MoA: Tricyclic antidepressant; Norepinephrine reputake inhibitor
SMILES: CNCCCC12CCC(c3ccccc13)c1ccccc21
InchiKey: QSLMDECMDJKHMQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2856 BRD-K25433859 HA1E 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
3167 BRD-K25433859 HCC515 10 uM 24 h -0.28 -1.17 0.49 0.31 1.09 0.67
3757 BRD-K25433859 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24567 BRD-K25433859 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25013 BRD-K25433859 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44904 BRD-K25433859 ASC 10 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
45208 BRD-K25433859 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.31 1.11 0.73
45474 BRD-K25433859 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46023 BRD-K25433859 NPC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
46341 BRD-K25433859 PHH 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
46657 BRD-K25433859 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99775 BRD-K25433859 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120974 BRD-K25433859 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121005 BRD-K25433859 HELA 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121131 BRD-K25433859 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129103 BRD-K25433859 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129233 BRD-K25433859 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).