CMap Candidate Details

Structure:
CMap ID: C10514
Pert ID: BRD-K25650355
Compound Name: physostigmine
Targets: ACHE
MoA: Cholinesterase inhibitor; Acetylcholinesterase inhibitor
SMILES: CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1
InchiKey: PIJVFDBKTWXHHD-HIFRSBDPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5440 BRD-K25650355 HA1E 10 uM 6 h -0.24 -0.98 0.13 0.0 0.0 0.0
5600 BRD-K25650355 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6532 BRD-K25650355 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37371 BRD-K25650355 A549 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.34
37622 BRD-K25650355 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37884 BRD-K25650355 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38450 BRD-K25650355 NPC 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
38931 BRD-K25650355 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91128 BRD-K25650355 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
120041 BRD-K25650355 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
120084 BRD-K25650355 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
120129 BRD-K25650355 MCF??7.00 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
120171 BRD-K25650355 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
128789 BRD-K25650355 A375 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
128857 BRD-K25650355 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).