CMap Candidate Details

Structure:
CMap ID: C01068
Pert ID: BRD-A43331270
Compound Name: niguldipine
Targets: ADRA1A; CACNA1C
MoA: Calcium channel blocker; Adrenergic receptor antagonist
SMILES: CCCN1C(C)=C(C(c2cccc(c2)[N+]([O-])=O)C(C(=O)ON2CCC(CC2)(c2ccccc2)c2ccccc2)=C1C)C(=O)OC
InchiKey: SLTFTBXXKKDMPA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8875 BRD-A43331270 A375 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
9144 BRD-A43331270 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9593 BRD-A43331270 H1299 10 uM 6 h 0.27 1.11 0.26 0.0 0.0 0.0
9968 BRD-A43331270 HA1E 10 uM 24 h 0.32 1.34 0.89 0.25 0.89 0.2
10217 BRD-A43331270 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10401 BRD-A43331270 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10668 BRD-A43331270 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.43 -1.44 15.35
10906 BRD-A43331270 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11217 BRD-A43331270 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
11342 BRD-A43331270 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.5
11655 BRD-A43331270 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11914 BRD-A43331270 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12208 BRD-A43331270 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12541 BRD-A43331270 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13148 BRD-A43331270 U937 10 uM 6 h -0.23 -0.96 0.09 0.23 0.8 0.08
13536 BRD-A43331270 VCAP 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.87
124366 BRD-A43331270 HELA 3.33 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
124435 BRD-A43331270 JURKAT 0.04 uM 24 h 0.19 0.8 0.0 -0.25 -0.86 0.2
124497 BRD-A43331270 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124559 BRD-A43331270 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132433 BRD-A43331270 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132507 BRD-A43331270 MCF10A 0.03 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
132624 BRD-A43331270 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).