CMap Candidate Details

Structure:
CMap ID: C01079
Pert ID: BRD-A43882281
Compound Name: pinacidil
Targets: ABCC9; ABCC8
MoA: ATP channel activator; Potassium channel activator
SMILES: CC(NC(Nc1ccncc1)=NC#N)C(C)(C)C
InchiKey: IVVNZDGDKPTYHK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4307 BRD-A43882281 HCC515 10 uM 24 h -0.22 -0.9 0.05 0.0 0.0 0.0
4859 BRD-A43882281 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37504 BRD-A43882281 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
37824 BRD-A43882281 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.39
38355 BRD-A43882281 NPC 10 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
38643 BRD-A43882281 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38863 BRD-A43882281 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90953 BRD-A43882281 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
123252 BRD-A43882281 A375 1.11 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.05
123283 BRD-A43882281 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123441 BRD-A43882281 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.28
123511 BRD-A43882281 YAPC 10 uM 24 h 0.23 0.96 0.08 0.27 0.95 0.31
131567 BRD-A43882281 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
131645 BRD-A43882281 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131672 BRD-A43882281 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131695 BRD-A43882281 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.43 1.51 2.27
131749 BRD-A43882281 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131804 BRD-A43882281 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131836 BRD-A43882281 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131876 BRD-A43882281 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131908 BRD-A43882281 MDAMB231 0.25 uM 24 h -0.21 -0.86 0.02 0.23 0.83 0.11
131943 BRD-A43882281 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).