CMap Candidate Details

Structure:
CMap ID: C10833
Pert ID: BRD-K26667523
Compound Name: TAK-733
Targets: MAP2K1
MoA: MEK inhibitor
SMILES: Cn1c2ncn(C[C@@H](O)CO)c(=O)c2c(Nc2ccc(I)cc2F)c(F)c1=O
InchiKey: RCLQNICOARASSR-SECBINFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121959 BRD-K26667523 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122051 BRD-K26667523 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122168 BRD-K26667523 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.18 -0.61 0.0
122194 BRD-K26667523 THP1 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
130186 BRD-K26667523 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130204 BRD-K26667523 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130230 BRD-K26667523 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130291 BRD-K26667523 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130319 BRD-K26667523 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
130352 BRD-K26667523 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130401 BRD-K26667523 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
130433 BRD-K26667523 MCF??7.00 0.74 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
130451 BRD-K26667523 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.54
130523 BRD-K26667523 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.8
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).