CMap Candidate Details

Structure:
CMap ID: C10835
Pert ID: BRD-K26674531
Compound Name: GR-235
Targets: NR1H4
MoA: FXR antagonist; Estrogen receptor agonist; Progesterone receptor agonist
SMILES: CC=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
InchiKey: WDXRGPWQVHZTQJ-OSJVMJFVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33639 BRD-K26674531 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33792 BRD-K26674531 A549 10 uM 24 h 0.32 1.33 0.85 0.29 1.01 0.46
34072 BRD-K26674531 ASC 10 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.64
34338 BRD-K26674531 HA1E 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.46
34588 BRD-K26674531 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34858 BRD-K26674531 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
35120 BRD-K26674531 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35308 BRD-K26674531 MCF??7.00 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
35757 BRD-K26674531 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35946 BRD-K26674531 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36234 BRD-K26674531 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
36528 BRD-K26674531 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36797 BRD-K26674531 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).