CMap Candidate Details

Structure:
CMap ID: C01089
Pert ID: BRD-A44090213
Compound Name: indoprofen
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor; Prostanoid receptor antagonist
SMILES: CC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
InchiKey: RJMIEHBSYVWVIN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8757 BRD-A44090213 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123250 BRD-A44090213 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123282 BRD-A44090213 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123326 BRD-A44090213 HELA 10 uM 24 h -0.32 -1.31 0.82 0.0 0.0 0.0
123439 BRD-A44090213 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
131565 BRD-A44090213 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131644 BRD-A44090213 HEK293 2.22 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
131694 BRD-A44090213 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131747 BRD-A44090213 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
131802 BRD-A44090213 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.42
131835 BRD-A44090213 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
131875 BRD-A44090213 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131907 BRD-A44090213 MDAMB231 0.08 uM 24 h -0.3 -1.23 0.64 0.0 0.0 0.0
131942 BRD-A44090213 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
131962 BRD-A44090213 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).