CMap Candidate Details

Structure:
CMap ID: C10891
Pert ID: BRD-K26838195
Compound Name: AST-1306
Targets: EGFR; ERBB2
MoA: EGFR inhibitor
SMILES: Fc1cccc(COc2ccc(Nc3ncnc4ccc(NC(=O)C=C)cc34)cc2Cl)c1
InchiKey: MVZGYPSXNDCANY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92868 BRD-K26838195 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92895 BRD-K26838195 A549 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
92932 BRD-K26838195 ASC 10 uM 24 h 0.15 0.63 0.0 -0.24 -0.81 0.12
92995 BRD-K26838195 CD34 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
93041 BRD-K26838195 HA1E 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
93083 BRD-K26838195 HEK293 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
93126 BRD-K26838195 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93171 BRD-K26838195 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.5
93221 BRD-K26838195 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
93276 BRD-K26838195 JURKAT 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
93315 BRD-K26838195 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93357 BRD-K26838195 MDAMB231 0.12 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
93418 BRD-K26838195 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93445 BRD-K26838195 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93485 BRD-K26838195 SKL 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
93543 BRD-K26838195 THP1 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
93583 BRD-K26838195 YAPC 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).