CMap Candidate Details

Structure:
CMap ID: C01098
Pert ID: BRD-A44780397
Compound Name: mifepristone
Targets: NR3C1; AR; PGR
MoA: Progesterone receptor antagonist; Glucocorticoid receptor antagonist
SMILES: CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C(CC21C)c5ccc(cc5)N(C)C
InchiKey: VKHAHZOOUSRJNA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2807 BRD-A44780397 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
3103 BRD-A44780397 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3686 BRD-A44780397 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39396 BRD-A44780397 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39568 BRD-A44780397 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39894 BRD-A44780397 HEPG2 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
40177 BRD-A44780397 HT29 10 uM 6 h -0.23 -0.97 0.1 0.0 0.0 0.0
40696 BRD-A44780397 NEU 10 uM 24 h 0.21 0.87 0.01 -0.24 -0.8 0.11
40994 BRD-A44780397 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41318 BRD-A44780397 SKB 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
95576 BRD-A44780397 MCF??7.00 10 uM 48 h -0.24 -0.99 0.14 0.0 0.0 0.0
95671 BRD-A44780397 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
96478 BRD-A44780397 A375 10 uM 24 h -0.23 -0.97 0.11 0.0 0.0 0.0
96545 BRD-A44780397 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).