CMap Candidate Details

Structure:
CMap ID: C10997
Pert ID: BRD-K27204852
Compound Name: balicatib
Targets: CTSK
MoA: Cathepsin inhibitor
SMILES: CCCN1CCN(CC1)c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
InchiKey: LLCRBOWRJOUJAE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120925 BRD-K27204852 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120981 BRD-K27204852 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.42 1.49 2.25
121008 BRD-K27204852 HELA 10 uM 3 h -0.22 -0.93 0.07 0.0 0.0 0.0
121064 BRD-K27204852 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121138 BRD-K27204852 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129106 BRD-K27204852 A375 0.03 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
129125 BRD-K27204852 A549 0.03 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
129210 BRD-K27204852 HT29 0.01 uM 24 h -0.27 -1.12 0.39 -0.29 -0.99 0.5
129238 BRD-K27204852 PC3 0.74 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).