CMap Candidate Details

Structure:
CMap ID: C11030
Pert ID: BRD-K27305650
Compound Name: LY-294002
Targets: MTOR; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PLK1; PRKDC
MoA: PLK inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; DNA dependent protein kinase inhibitor
SMILES: O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
InchiKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1239 BRD-K27305650 A549 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
6736 BRD-K27305650 A375 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
7435 BRD-K27305650 HA1E 10 uM 6 h 0.0 0.0 0.0 0.25 0.9 0.21
7641 BRD-K27305650 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7990 BRD-K27305650 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
59561 BRD-K27305650 VCAP 10 uM 6 h 0.18 0.77 0.0 -0.35 -1.18 1.14
82021 BRD-K27305650 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88621 BRD-K27305650 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
95746 BRD-K27305650 NPC 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.05
95915 BRD-K27305650 YAPC 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
96066 BRD-K27305650 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97282 BRD-K27305650 HAP1 3.33 uM 24 h 0.24 1.0 0.11 -0.28 -0.93 0.34
97447 BRD-K27305650 NKDBA 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
97810 BRD-K27305650 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
110145 BRD-K27305650 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).