CMap Candidate Details

Structure:
CMap ID: C11091
Pert ID: BRD-K27499107
Compound Name: carbacyclin
Targets: PPARD; PTGIR
MoA: IP receptor activator; PPAR receptor agonist
SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2C/C(=CCCCC(=O)O)/C[C@H]12
InchiKey: XZFRIPGNUQRGPI-WBQKLGIQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1008 BRD-K27499107 CD34 3.33 uM 6 h -0.3 -1.25 0.71 -0.48 -1.62 15.65
1076 BRD-K27499107 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1110 BRD-K27499107 U937 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
4208 BRD-K27499107 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4401 BRD-K27499107 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4912 BRD-K27499107 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44354 BRD-K27499107 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44556 BRD-K27499107 A549 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
44913 BRD-K27499107 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45483 BRD-K27499107 HT29 10 uM 6 h -0.22 -0.9 0.04 0.26 0.92 0.25
45675 BRD-K27499107 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46348 BRD-K27499107 PHH 10 uM 24 h 0.24 1.01 0.11 0.24 0.86 0.15
46666 BRD-K27499107 SKB 10 uM 24 h -0.27 -1.11 0.36 -0.28 -0.95 0.41
98749 BRD-K27499107 NPC 10 uM 24 h -0.21 -0.87 0.02 -0.29 -0.99 0.5
98879 BRD-K27499107 NEU 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
99790 BRD-K27499107 U2OS 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).