CMap Candidate Details

Structure:
CMap ID: C11166
Pert ID: BRD-K27737647
Compound Name: H-89
Targets: PRKACA
MoA: PKA inhibitor
SMILES: Brc1ccc(C=CCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
InchiKey: ZKZXNDJNWUTGDK-NSCUHMNNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1573 BRD-K27737647 HA1E 10 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
1908 BRD-K27737647 HCC515 10 uM 24 h 0.0 0.0 0.0 0.4 1.4 2.18
2163 BRD-K27737647 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2647 BRD-K27737647 VCAP 10 uM 6 h 0.0 0.0 0.0 0.34 1.19 1.02
41925 BRD-K27737647 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
42340 BRD-K27737647 ASC 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
42666 BRD-K27737647 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42971 BRD-K27737647 HT29 10 uM 6 h -0.24 -0.99 0.14 0.28 0.99 0.39
43312 BRD-K27737647 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.32
43532 BRD-K27737647 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43830 BRD-K27737647 PHH 10 uM 24 h 0.24 0.99 0.09 -0.3 -1.01 0.58
44101 BRD-K27737647 SKB 10 uM 24 h 0.0 0.0 0.0 0.28 0.97 0.36
97276 BRD-K27737647 HAP1 3.33 uM 24 h -0.27 -1.13 0.4 -0.28 -0.96 0.43
97367 BRD-K27737647 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99792 BRD-K27737647 U2OS 10 uM 6 h 0.23 0.95 0.06 0.35 1.24 1.26
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).