CMap Candidate Details

Structure:
CMap ID: C01120
Pert ID: BRD-A45889380
Compound Name: mepacrine
Targets: TP53
MoA: TP53 activator; NFKB pathway inhibitor; Cytokine production inhibitor
SMILES: CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
InchiKey: GPKJTRJOBQGKQK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9036 BRD-A45889380 A375 10 uM 6 h -0.29 -1.21 0.57 0.0 0.0 0.0
9292 BRD-A45889380 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9594 BRD-A45889380 H1299 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
10164 BRD-A45889380 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10402 BRD-A45889380 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.5
10669 BRD-A45889380 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11076 BRD-A45889380 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11343 BRD-A45889380 NCIH2073 10 uM 6 h 0.22 0.93 0.05 0.0 0.0 0.0
11656 BRD-A45889380 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.38
11915 BRD-A45889380 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.38 2.02
12667 BRD-A45889380 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13007 BRD-A45889380 THP1 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.34
13149 BRD-A45889380 U937 10 uM 6 h -0.25 -1.03 0.19 0.0 0.0 0.0
13423 BRD-A45889380 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51378 BRD-A45889380 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97270 BRD-A45889380 HAP1 3.33 uM 24 h -0.22 -0.9 0.04 0.24 0.86 0.16
125618 BRD-A45889380 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125632 BRD-A45889380 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
125675 BRD-A45889380 HELA 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
125741 BRD-A45889380 HUVEC 10 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
125781 BRD-A45889380 JURKAT 10 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
125803 BRD-A45889380 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.84
125854 BRD-A45889380 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125939 BRD-A45889380 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133735 BRD-A45889380 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133947 BRD-A45889380 PC3 2.22 uM 24 h -0.2 -0.85 0.01 0.23 0.81 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).