CMap Candidate Details

Structure:
CMap ID: C01122
Pert ID: BRD-A46179541
Compound Name: doxapram
Targets: KCNK3; KCNK9
MoA: Potassium channel blocker
SMILES: CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
InchiKey: XFDJYSQDBULQSI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22098 BRD-A46179541 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
22646 BRD-A46179541 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22927 BRD-A46179541 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.06
23512 BRD-A46179541 MCF??7.00 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
24263 BRD-A46179541 VCAP 10 uM 6 h 0.27 1.13 0.29 -0.34 -1.15 1.07
125236 BRD-A46179541 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125305 BRD-A46179541 HEK293 0.04 uM 24 h 0.25 1.02 0.13 0.15 0.52 0.0
125492 BRD-A46179541 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133385 BRD-A46179541 HA1E 0.03 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
133415 BRD-A46179541 HELA 0.74 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
133450 BRD-A46179541 HT29 0.01 uM 24 h 0.22 0.9 0.02 0.28 1.0 0.42
133479 BRD-A46179541 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133511 BRD-A46179541 MCF10A 0.03 uM 24 h 0.2 0.83 0.0 0.26 0.93 0.27
133548 BRD-A46179541 MDAMB231 0.08 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
133603 BRD-A46179541 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133626 BRD-A46179541 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).