CMap Candidate Details

Structure:
CMap ID: C11303
Pert ID: BRD-K28137194
Compound Name: loreclezole
Targets: GABRB2; GABRB3
MoA: GABA receptor agonist
SMILES: ClC(=Cn1cncn1)c2ccc(Cl)cc2Cl
InchiKey: XGLHZTBDUXXHOM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4209 BRD-K28137194 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4403 BRD-K28137194 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4668 BRD-K28137194 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5063 BRD-K28137194 VCAP 10 uM 6 h 0.0 0.0 0.0 0.33 1.17 0.96
39109 BRD-K28137194 A375 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.34
39657 BRD-K28137194 ASC 10 uM 24 h -0.2 -0.82 0.0 0.24 0.87 0.16
39973 BRD-K28137194 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40249 BRD-K28137194 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40603 BRD-K28137194 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40777 BRD-K28137194 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41079 BRD-K28137194 NPC 10 uM 24 h 0.22 0.93 0.05 0.25 0.89 0.21
41411 BRD-K28137194 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96010 BRD-K28137194 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).