CMap Candidate Details

Structure:
CMap ID: C11368
Pert ID: BRD-K28346421
Compound Name: rifapentine
Targets: CYP2C8; CYP2C9; CYP3A4
MoA: RNA polymerase inhibitor
SMILES: CO[C@H]1C=CO[C@@]2(C)Oc3c(C2=O)c2c(O)c(C=NN4CCN(CC4)C4CCCC4)c(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C
InchiKey: WDZCUPBHRAEYDL-NAFQJNKLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
19002 BRD-K28346421 A375 10 uM 6 h -0.27 -1.12 0.39 0.0 0.0 0.0
19438 BRD-K28346421 A549 10 uM 6 h -0.28 -1.19 0.52 -0.24 -0.81 0.13
19650 BRD-K28346421 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
19975 BRD-K28346421 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20307 BRD-K28346421 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20631 BRD-K28346421 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
20883 BRD-K28346421 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
21227 BRD-K28346421 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
21729 BRD-K28346421 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).