CMap Candidate Details

Structure:
CMap ID: C11375
Pert ID: BRD-K28360340
Compound Name: TW-37
Targets: MCL1; BCL2; BCL2L1
MoA: BCL inhibitor
SMILES: CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(cc2)S(=O)(=O)c2ccccc2C(C)(C)C)c(O)c(O)c1O
InchiKey: PQAPVTKIEGUPRN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1141 BRD-K28360340 A549 0.08 uM 24 h 0.17 0.72 0.0 -0.4 -1.35 2.02
1369 BRD-K28360340 U2OS 0.08 uM 48 h -0.28 -1.17 0.48 -0.34 -1.14 1.01
9399 BRD-K28360340 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9710 BRD-K28360340 H1299 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.99 0.51
10205 BRD-K28360340 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10494 BRD-K28360340 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11461 BRD-K28360340 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.33 1.17 0.95
12025 BRD-K28360340 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12772 BRD-K28360340 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13249 BRD-K28360340 U937 10 uM 6 h 0.24 1.0 0.11 0.0 0.0 0.0
13465 BRD-K28360340 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118376 BRD-K28360340 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118447 BRD-K28360340 HA1E 0.37 uM 24 h -0.17 -0.72 0.0 0.0 0.0 0.0
118533 BRD-K28360340 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
118576 BRD-K28360340 HT29 10 uM 24 h -0.17 -0.71 0.0 0.0 0.0 0.0
118612 BRD-K28360340 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
118644 BRD-K28360340 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).