CMap Candidate Details

Structure:
CMap ID: C11450
Pert ID: BRD-K28578425
Compound Name: cilostamide
Targets: PDE3A; PDE3B
MoA: Phosphodiesterase inhibitor
SMILES: CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
InchiKey: UIAYVIIHMORPSJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2860 BRD-K28578425 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3764 BRD-K28578425 VCAP 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
39312 BRD-K28578425 A549 10 uM 24 h 0.23 0.97 0.08 0.28 1.0 0.43
39660 BRD-K28578425 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40605 BRD-K28578425 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40780 BRD-K28578425 NEU 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.06
41082 BRD-K28578425 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41414 BRD-K28578425 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91369 BRD-K28578425 HUH7 10 uM 72 h 0.3 1.27 0.58 0.2 0.71 0.02
99801 BRD-K28578425 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.09
119177 BRD-K28578425 A375 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119263 BRD-K28578425 HCC515 3.33 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
119293 BRD-K28578425 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119321 BRD-K28578425 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119371 BRD-K28578425 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).