CMap Candidate Details
Structure:
| CMap ID: | C01148 |
| Pert ID: | BRD-A47513740 |
| Compound Name: | calyculin |
| Targets: | PPP1CA; PPP2CA |
| MoA: | Protein phosphatase inhibitor |
| SMILES: | COC[C@H]([C@@H](O)[C@@H](O)C(=O)NCC[C@@H](C)c1nc(/C=C/C[C@H]2OC3(C[C@H](O)[C@H]2C)OC([C@@H](C[C@@H](O)[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C)/C(=C/C=C/C(=CC#N)/C)/C)OC)[C@@H](OP(=O)(O)O)C3(C)C)co1)N(C)C |
| InchiKey: | FKAWLXNLHHIHLA-OQLQHIBWSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 6650 | BRD-A47513740 | A375 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 7079 | BRD-A47513740 | A549 | 10 uM | 6 h | -0.23 | -0.95 | 0.09 | -0.53 | -1.8 | 15.65 |
| 7395 | BRD-A47513740 | HA1E | 10 uM | 6 h | -0.29 | -1.2 | 0.55 | -0.4 | -1.36 | 2.02 |
| 7547 | BRD-A47513740 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.3 | 1.66 |
| 7952 | BRD-A47513740 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.39 | 2.02 |
| 8165 | BRD-A47513740 | MCF??7.00 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 8449 | BRD-A47513740 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.43 | -1.46 | 15.35 |
| 8760 | BRD-A47513740 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.29 | 1.53 |
| 100182 | BRD-A47513740 | U2OS | 0.5 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |