CMap Candidate Details

Structure:
CMap ID: C11533
Pert ID: BRD-K28849549
Compound Name: mesalazine
Targets: ALOX5; PPARG; PTGS1; PTGS2
MoA: Lipoxygenase inhibitor; Cyclooxygenase inhibitor; Prostanoid receptor antagonist
SMILES: Nc1ccc(O)c(c1)C(O)=O
InchiKey: KBOPZPXVLCULAV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24425 BRD-K28849549 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24569 BRD-K28849549 A549 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.56
24888 BRD-K28849549 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.95
25014 BRD-K28849549 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25243 BRD-K28849549 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25346 BRD-K28849549 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91352 BRD-K28849549 HUH7 20 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).