CMap Candidate Details

Structure:
CMap ID: C11568
Pert ID: BRD-K28936863
Compound Name: ketotifen
Targets: HRH1
MoA: Histamine receptor ligand; Histamine receptor agonist; Phosphodiesterase inhibitor; Leukotriene receptor antagonist
SMILES: CN1CCC(CC1)=C1c2ccsc2C(=O)Cc2ccccc12
InchiKey: ZCVMWBYGMWKGHF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5602 BRD-K28936863 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24141 BRD-K28936863 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37628 BRD-K28936863 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37889 BRD-K28936863 HEPG2 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
38455 BRD-K28936863 NPC 10 uM 24 h 0.18 0.75 0.0 0.27 0.96 0.33
38704 BRD-K28936863 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38936 BRD-K28936863 SKB 10 uM 24 h 0.22 0.92 0.04 -0.31 -1.04 0.68
91298 BRD-K28936863 HUH7 10 uM 72 h 0.0 0.0 0.0 0.25 0.9 0.22
97575 BRD-K28936863 NKDBA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121887 BRD-K28936863 A375 0.125 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
121933 BRD-K28936863 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122037 BRD-K28936863 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122102 BRD-K28936863 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122184 BRD-K28936863 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
122213 BRD-K28936863 YAPC 0.125 uM 24 h -0.27 -1.11 0.37 0.0 0.0 0.0
130196 BRD-K28936863 A549 2.22 uM 24 h -0.33 -1.36 1.06 0.0 0.0 0.0
130250 BRD-K28936863 HEK293 0.08 uM 24 h 0.27 1.13 0.28 0.0 0.0 0.0
130280 BRD-K28936863 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
130314 BRD-K28936863 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130339 BRD-K28936863 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130389 BRD-K28936863 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130444 BRD-K28936863 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130475 BRD-K28936863 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).