CMap Candidate Details

Structure:
CMap ID: C11581
Pert ID: BRD-K28984613
Compound Name: dutasteride
Targets: SRD5A1; SRD5A2
MoA: 5 alpha reductase inhibitor
SMILES: C[C@]12CC[C@@H]3[C@@H](CC[C@H]4NC(=O)C=C[C@]34C)[C@@H]1CC[C@H]2C(=O)Nc1cc(ccc1C(F)(F)F)C(F)(F)F
InchiKey: JWJOTENAMICLJG-UUJLXMGASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
119952 BRD-K28984613 A375 10 uM 24 h 0.31 1.29 0.67 0.23 0.81 0.09
119994 BRD-K28984613 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120029 BRD-K28984613 HA1E 10 uM 24 h 0.32 1.35 0.96 0.26 0.94 0.28
120056 BRD-K28984613 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120111 BRD-K28984613 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120153 BRD-K28984613 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120189 BRD-K28984613 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128876 BRD-K28984613 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.42
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).