CMap Candidate Details

Structure:
CMap ID: C11612
Pert ID: BRD-K29113274
Compound Name: ketoconazole
Targets: CYP19A1; AR
MoA: Sterol demethylase inhibitor
SMILES: CC(=O)N1CCN(CC1)c1ccc(OC[C@H]2CO[C@@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
InchiKey: XMAYWYJOQHXEEK-OZXSUGGESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24662 BRD-K29113274 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24889 BRD-K29113274 HT29 10 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.33
25015 BRD-K29113274 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.4
25347 BRD-K29113274 VCAP 10 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
91141 BRD-K29113274 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96575 BRD-K29113274 A375 1.11 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
96646 BRD-K29113274 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99807 BRD-K29113274 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).