CMap Candidate Details

Structure:
CMap ID: C01172
Pert ID: BRD-A48430263
Compound Name: pioglitazone
Targets: PPARG
MoA: Insulin sensitizer; PPAR receptor agonist
SMILES: CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
InchiKey: HYAFETHFCAUJAY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5522 BRD-A48430263 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5841 BRD-A48430263 HEPG2 10 uM 6 h -0.24 -0.99 0.13 0.0 0.0 0.0
25475 BRD-A48430263 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37344 BRD-A48430263 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37507 BRD-A48430263 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38865 BRD-A48430263 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51400 BRD-A48430263 PC3 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
90764 BRD-A48430263 HPTEC 100 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
91305 BRD-A48430263 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95664 BRD-A48430263 U2OS 0.12 uM 48 h 0.0 0.0 0.0 -0.3 -1.0 0.53
98785 BRD-A48430263 NPC 10 uM 6 h 0.24 1.01 0.11 -0.34 -1.16 1.11
98974 BRD-A48430263 NEU 10 uM 6 h -0.22 -0.92 0.06 -0.24 -0.82 0.14
124570 BRD-A48430263 A375 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
124682 BRD-A48430263 HT29 1.11 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
124716 BRD-A48430263 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124783 BRD-A48430263 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132714 BRD-A48430263 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132741 BRD-A48430263 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132782 BRD-A48430263 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132859 BRD-A48430263 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132894 BRD-A48430263 MCF??7.00 0.03 uM 24 h 0.15 0.63 0.0 0.0 0.0 0.0
132925 BRD-A48430263 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132944 BRD-A48430263 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).