CMap Candidate Details

Structure:
CMap ID: C01175
Pert ID: BRD-A48631911
Compound Name: mibefradil
Targets: CACNA1C; CACNA1I; CACNA1H; CACNA1G
MoA: T-type calcium channel blocker
SMILES: COCC(=O)OC1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2C1C(C)C
InchiKey: HBNPJJILLOYFJU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49765 BRD-A48631911 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
49944 BRD-A48631911 A549 10 uM 6 h -0.25 -1.06 0.25 0.24 0.85 0.14
50107 BRD-A48631911 HA1E 10 uM 6 h 0.28 1.17 0.36 0.0 0.0 0.0
50294 BRD-A48631911 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50459 BRD-A48631911 HT29 10 uM 6 h 0.0 0.0 0.0 0.4 1.41 2.19
50714 BRD-A48631911 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.97
50886 BRD-A48631911 PC3 10 uM 6 h 0.0 0.0 0.0 -0.42 -1.4 2.02
50983 BRD-A48631911 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).