CMap Candidate Details

Structure:
CMap ID: C11767
Pert ID: BRD-K29582115
Compound Name: ziprasidone
Targets: DRD2; HRH1; HTR1A; HTR1B; HTR1D; HTR1E; HTR2A; HTR2C; HTR7
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
InchiKey: MVWVFYHBGMAFLY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1419 BRD-K29582115 NPC 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34075 BRD-K29582115 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34590 BRD-K29582115 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.62
34860 BRD-K29582115 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36237 BRD-K29582115 PHH 10 uM 24 h -0.31 -1.31 0.82 0.24 0.85 0.15
36531 BRD-K29582115 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36800 BRD-K29582115 VCAP 10 uM 24 h 0.0 0.0 0.0 0.35 1.22 1.18
119954 BRD-K29582115 A375 10 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
119998 BRD-K29582115 A549 0.37 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
120059 BRD-K29582115 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120114 BRD-K29582115 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120157 BRD-K29582115 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120218 BRD-K29582115 YAPC 10 uM 24 h -0.19 -0.81 0.0 0.0 0.0 0.0
128817 BRD-K29582115 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128850 BRD-K29582115 PC3 0.08 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).