CMap Candidate Details

Structure:
CMap ID: C11791
Pert ID: BRD-K29653726
Compound Name: topiramate
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GRIA1; GRIK1; GABRQ; SCN1A; SCN5A; CA2; CA4
MoA: Kainate receptor antagonist; Carbonic anhydrase inhibitor; Glutamate receptor antagonist
SMILES: CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
InchiKey: KJADKKWYZYXHBB-XBWDGYHZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1428 BRD-K29653726 NPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24891 BRD-K29653726 HT29 10 uM 6 h 0.21 0.88 0.01 -0.31 -1.06 0.72
25349 BRD-K29653726 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119999 BRD-K29653726 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120158 BRD-K29653726 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
128798 BRD-K29653726 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128818 BRD-K29653726 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128830 BRD-K29653726 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128851 BRD-K29653726 PC3 0.74 uM 24 h -0.27 -1.11 0.36 0.3 1.05 0.56
128880 BRD-K29653726 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).