CMap Candidate Details

Structure:
CMap ID: C11794
Pert ID: BRD-K29656036
Compound Name: MK-8245
Targets: SCD
MoA: Stearoyl-CoA desaturase inhibitor
SMILES: OC(=O)Cn1nnc(n1)-c1cc(no1)N1CCC(CC1)Oc1cc(F)ccc1Br
InchiKey: UJEAABFSXKCSGI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90610 BRD-K29656036 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90652 BRD-K29656036 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98043 BRD-K29656036 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98098 BRD-K29656036 P1A82 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
119957 BRD-K29656036 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120002 BRD-K29656036 A549 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
120032 BRD-K29656036 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120118 BRD-K29656036 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120195 BRD-K29656036 PC3 1.11 uM 24 h -0.23 -0.98 0.12 -0.25 -0.83 0.16
120220 BRD-K29656036 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128838 BRD-K29656036 HELA 2.22 uM 3 h -0.23 -0.98 0.12 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).