CMap Candidate Details

Structure:
CMap ID: C11818
Pert ID: BRD-K29733039
Compound Name: deforolimus
Targets: MTOR
MoA: MTOR inhibitor
SMILES: CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=C/C=C(C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OP(C)(C)=O
InchiKey: BUROJSBIWGDYCN-LWCFFJEVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29824 BRD-K29733039 A375 10 uM 6 h -0.26 -1.07 0.28 0.0 0.0 0.0
30412 BRD-K29733039 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30723 BRD-K29733039 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31012 BRD-K29733039 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31317 BRD-K29733039 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31563 BRD-K29733039 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32014 BRD-K29733039 MCF??7.00 10 uM 6 h -0.16 -0.66 0.0 0.35 1.25 1.28
32759 BRD-K29733039 PC3 10 uM 6 h -0.29 -1.21 0.58 0.0 0.0 0.0
32995 BRD-K29733039 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33269 BRD-K29733039 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96039 BRD-K29733039 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96129 BRD-K29733039 A549 10 uM 24 h -0.21 -0.86 0.02 -0.27 -0.92 0.34
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).