CMap Candidate Details

Structure:
CMap ID: C01183
Pert ID: BRD-A49160188
Compound Name: donepezil
Targets: ACHE
MoA: Acetylcholinesterase inhibitor
SMILES: COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC
InchiKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5404 BRD-A49160188 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.78
5523 BRD-A49160188 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
5842 BRD-A49160188 HEPG2 10 uM 6 h -0.33 -1.37 1.08 0.0 0.0 0.0
6135 BRD-A49160188 PC3 10 uM 24 h -0.24 -1.0 0.14 -0.28 -0.93 0.35
6406 BRD-A49160188 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37082 BRD-A49160188 A375 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.75
37242 BRD-A49160188 A549 10 uM 24 h 0.28 1.19 0.41 0.27 0.95 0.31
37510 BRD-A49160188 ASC 10 uM 24 h -0.25 -1.05 0.24 0.2 0.69 0.01
38359 BRD-A49160188 NPC 10 uM 24 h -0.23 -0.95 0.08 0.0 0.0 0.0
125326 BRD-A49160188 HEK293 0.125 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
125407 BRD-A49160188 JURKAT 10 uM 24 h -0.23 -0.95 0.09 -0.31 -1.03 0.64
125454 BRD-A49160188 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.4 -1.36 2.02
133430 BRD-A49160188 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133460 BRD-A49160188 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133525 BRD-A49160188 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133562 BRD-A49160188 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133609 BRD-A49160188 THP1 2.22 uM 24 h 0.29 1.2 0.44 0.29 1.04 0.53
133640 BRD-A49160188 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).