CMap Candidate Details

Structure:
CMap ID: C11861
Pert ID: BRD-K29905972
Compound Name: axitinib
Targets: FLT1; FLT4; KDR
MoA: PDGFR inhibitor; VEGFR inhibitor
SMILES: CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1
InchiKey: RITAVMQDGBJQJZ-FMIVXFBMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1190 BRD-K29905972 PC3 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
1221 BRD-K29905972 A549 10 uM 24 h -0.21 -0.85 0.01 0.27 0.96 0.34
1302 BRD-K29905972 MCF??7.00 10 uM 6 h 0.22 0.93 0.04 0.31 1.09 0.67
30413 BRD-K29905972 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32398 BRD-K29905972 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32996 BRD-K29905972 SKB 10 uM 24 h 0.26 1.09 0.23 0.35 1.23 1.23
33453 BRD-K29905972 VCAP 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.16
95675 BRD-K29905972 U2OS 10 uM 48 h -0.17 -0.72 0.0 0.0 0.0 0.0
118051 BRD-K29905972 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118138 BRD-K29905972 HA1E 10 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
118184 BRD-K29905972 HCC515 3.33 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
118233 BRD-K29905972 HEPG2 3.33 uM 24 h -0.22 -0.9 0.04 -0.31 -1.05 0.7
118277 BRD-K29905972 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).