CMap Candidate Details

Structure:
CMap ID: C11890
Pert ID: BRD-K30020243
Compound Name: aliskiren
Targets: REN
MoA: Renin inhibitor; Protease inhibitor; Peptidase inhibitor; Anti-hypertensive agent
SMILES: COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)ccc1OC
InchiKey: UXOWGYHJODZGMF-QORCZRPOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5606 BRD-K30020243 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6421 BRD-K30020243 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37376 BRD-K30020243 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37631 BRD-K30020243 ASC 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
37891 BRD-K30020243 HEPG2 10 uM 6 h 0.21 0.88 0.02 -0.35 -1.18 1.15
38458 BRD-K30020243 NPC 10 uM 24 h -0.25 -1.05 0.24 0.24 0.85 0.14
38707 BRD-K30020243 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38938 BRD-K30020243 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121900 BRD-K30020243 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121962 BRD-K30020243 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122057 BRD-K30020243 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.53
122111 BRD-K30020243 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122196 BRD-K30020243 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.1
130235 BRD-K30020243 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130294 BRD-K30020243 HELA 0.08 uM 24 h 0.25 1.05 0.17 0.33 1.16 0.91
130323 BRD-K30020243 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130358 BRD-K30020243 JURKAT 0.08 uM 24 h -0.26 -1.1 0.34 -0.28 -0.94 0.38
130406 BRD-K30020243 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130455 BRD-K30020243 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130481 BRD-K30020243 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130529 BRD-K30020243 YAPC 2.22 uM 24 h -0.27 -1.12 0.38 0.24 0.85 0.14
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).