CMap Candidate Details

Structure:
CMap ID: C11907
Pert ID: BRD-K30097969
Compound Name: pitavastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: O[C@H](C[C@H](O)/C=C/c1c(nc2ccccc2c1c3ccc(F)cc3)C4CC4)CC(=O)O[Ca]OC(=O)C[C@H](O)C[C@H](O)/C=C/c5c(nc6ccccc6c5c7ccc(F)cc7)C8CC8
InchiKey: RHGYHLPFVJEAOC-FFNUKLMVSA-L
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22072 BRD-K30097969 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22274 BRD-K30097969 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22466 BRD-K30097969 HA1E 10 uM 6 h -0.22 -0.91 0.05 -0.25 -0.85 0.19
22738 BRD-K30097969 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23025 BRD-K30097969 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23328 BRD-K30097969 HT29 10 uM 6 h 0.0 0.0 0.0 0.21 0.75 0.04
23563 BRD-K30097969 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
23984 BRD-K30097969 PC3 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
24142 BRD-K30097969 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).