CMap Candidate Details

Structure:
CMap ID: C11935
Pert ID: BRD-K30189597
Compound Name: SYK-inhibitor
Targets: SYK
MoA: Syk inhibitor
SMILES: Cn1cc(/C=C/2C(=O)Nc3ccc(cc23)S(=O)(=O)N)c4ccccc14
InchiKey: MLKHXLFEYOOYEY-NVNXTCNLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1579 BRD-K30189597 HA1E 10 uM 24 h 0.23 0.95 0.06 -0.32 -1.08 0.79
2101 BRD-K30189597 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2308 BRD-K30189597 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2794 BRD-K30189597 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.74
41762 BRD-K30189597 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42349 BRD-K30189597 ASC 10 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
42675 BRD-K30189597 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42979 BRD-K30189597 HT29 10 uM 6 h 0.0 0.0 0.0 0.21 0.74 0.04
43313 BRD-K30189597 MCF??7.00 10 uM 6 h 0.31 1.28 0.64 0.25 0.9 0.22
43540 BRD-K30189597 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
43838 BRD-K30189597 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44108 BRD-K30189597 SKB 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
96130 BRD-K30189597 A549 10 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).