CMap Candidate Details

Structure:
CMap ID: C12012
Pert ID: BRD-K30421593
Compound Name: timolol
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: CC(C)(C)NC[C@@H](O)COc1nsnc1N1CCOCC1
InchiKey: BLJRIMJGRPQVNF-SNVBAGLBSA-N
Compound Aliases: timolol-maleate

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
117145 BRD-K30421593 HCC515 0.125 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
117190 BRD-K30421593 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117236 BRD-K30421593 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117274 BRD-K30421593 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
119960 BRD-K30421593 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120006 BRD-K30421593 A549 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
120035 BRD-K30421593 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120199 BRD-K30421593 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120223 BRD-K30421593 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128831 BRD-K30421593 HELA 0.08 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).