CMap Candidate Details

Structure:
CMap ID: C12050
Pert ID: BRD-K30550578
Compound Name: PF-04620110
Targets: DGAT1
MoA: Diacylglycerol O acyltransferase inhibitor
SMILES: Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
InchiKey: GEVVQZHMFVFGLN-HDJSIYSDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121938 BRD-K30550578 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121965 BRD-K30550578 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121986 BRD-K30550578 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122015 BRD-K30550578 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122061 BRD-K30550578 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122115 BRD-K30550578 MCF??7.00 0.04 uM 24 h -0.22 -0.93 0.07 -0.35 -1.16 1.11
122146 BRD-K30550578 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122199 BRD-K30550578 THP1 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
122222 BRD-K30550578 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130188 BRD-K30550578 A375 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130208 BRD-K30550578 A549 0.08 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
130362 BRD-K30550578 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130409 BRD-K30550578 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
130482 BRD-K30550578 PC3 0.01 uM 24 h 0.21 0.86 0.01 0.21 0.75 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).