CMap Candidate Details

Structure:
CMap ID: C01206
Pert ID: BRD-A50311610
Compound Name: meclizine
Targets: NR1I3
MoA: CAR agonist
SMILES: Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1
InchiKey: OCJYIGYOJCODJL-UHFFFAOYSA-N
Compound Aliases: meclozine

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3688 BRD-A50311610 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44770 BRD-A50311610 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45090 BRD-A50311610 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.24 0.83 0.12
45889 BRD-A50311610 NPC 10 uM 24 h 0.28 1.17 0.38 -0.32 -1.08 0.81
46205 BRD-A50311610 PHH 10 uM 24 h 0.25 1.04 0.15 -0.35 -1.17 1.11
46520 BRD-A50311610 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50297 BRD-A50311610 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
100198 BRD-A50311610 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.13
124609 BRD-A50311610 HA1E 10 uM 24 h -0.23 -0.95 0.09 -0.21 -0.71 0.03
124636 BRD-A50311610 HEK293 10 uM 24 h -0.21 -0.89 0.03 -0.37 -1.23 1.28
124652 BRD-A50311610 HELA 10 uM 24 h 0.26 1.1 0.24 0.23 0.81 0.09
124683 BRD-A50311610 HT29 1.11 uM 24 h -0.32 -1.35 0.98 -0.26 -0.88 0.26
124717 BRD-A50311610 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.18 0.65 0.01
124754 BRD-A50311610 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124785 BRD-A50311610 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124828 BRD-A50311610 PC3 1.11 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
124871 BRD-A50311610 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132657 BRD-A50311610 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132680 BRD-A50311610 A549 0.74 uM 24 h -0.19 -0.78 0.0 -0.26 -0.88 0.26
132861 BRD-A50311610 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
132945 BRD-A50311610 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.43
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).