CMap Candidate Details

Structure:
CMap ID: C12064
Pert ID: BRD-K30577245
Compound Name: docetaxel
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Compound Aliases: docetaxil

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87291 BRD-K30577245 BJAB 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87369 BRD-K30577245 HBL1 0.66 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
87419 BRD-K30577245 K562 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87466 BRD-K30577245 KMS34 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87489 BRD-K30577245 MINO 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87571 BRD-K30577245 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87621 BRD-K30577245 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87671 BRD-K30577245 OCILY19 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87722 BRD-K30577245 OCILY3 0.125 uM 24 h 0.24 1.0 0.1 0.0 0.0 0.0
87770 BRD-K30577245 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.16
87793 BRD-K30577245 THP1 0.66 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
87837 BRD-K30577245 TMD8 0.125 uM 24 h -0.26 -1.07 0.27 -0.23 -0.79 0.1
91088 BRD-K30577245 HUH7 4 uM 72 h -0.22 -0.94 0.07 -0.28 -0.93 0.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).