CMap Candidate Details

Structure:
CMap ID: C01209
Pert ID: BRD-A50454580
Compound Name: PD-0325901
Targets: MAP2K1
MoA: MEK inhibitor; MAP kinase inhibitor; Protein kinase inhibitor
SMILES: OCC(O)CONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F
InchiKey: SUDAHWBOROXANE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33634 BRD-A50454580 A375 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.89
33748 BRD-A50454580 A549 10 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
33993 BRD-A50454580 ASC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
34270 BRD-A50454580 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34506 BRD-A50454580 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34776 BRD-A50454580 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
35050 BRD-A50454580 HT29 10 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
35430 BRD-A50454580 MCF??7.00 10 uM 6 h 0.22 0.94 0.05 0.36 1.27 1.34
35687 BRD-A50454580 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36044 BRD-A50454580 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36150 BRD-A50454580 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36445 BRD-A50454580 SKB 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
36931 BRD-A50454580 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91139 BRD-A50454580 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).