CMap Candidate Details

Structure:
CMap ID: C12114
Pert ID: BRD-K30707190
Compound Name: PNU-74654
Targets: CTNNB1; TCF4
MoA: Beta-catenin inhibitor
SMILES: Cc1ccc(C=NNC(=O)c2ccccc2Oc2ccccc2)o1
InchiKey: JJEDWBQZCRESJL-DEDYPNTBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8931 BRD-K30707190 A375 80 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.74
9196 BRD-K30707190 A549 80 uM 6 h 0.0 0.0 0.0 -0.47 -1.57 15.65
9404 BRD-K30707190 AGS 80 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.68
9713 BRD-K30707190 H1299 80 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
10053 BRD-K30707190 HA1E 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10130 BRD-K30707190 HCC515 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10499 BRD-K30707190 HCT116 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10771 BRD-K30707190 HEPG2 80 uM 6 h 0.0 0.0 0.0 -0.54 -1.82 15.65
11062 BRD-K30707190 HT29 80 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.57
11143 BRD-K30707190 MCF??7.00 80 uM 24 h 0.0 0.0 0.0 -0.33 -1.13 0.98
11466 BRD-K30707190 NCIH2073 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12029 BRD-K30707190 NCIH596 80 uM 6 h -0.25 -1.04 0.22 -0.33 -1.11 0.91
12300 BRD-K30707190 NOMO1 80 uM 6 h -0.28 -1.19 0.51 0.0 0.0 0.0
12448 BRD-K30707190 PC3 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13254 BRD-K30707190 U937 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13610 BRD-K30707190 VCAP 80 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
90900 BRD-K30707190 MCF10A 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98883 BRD-K30707190 NEU 10 uM 24 h 0.0 0.0 0.0 0.35 1.22 1.19
99137 BRD-K30707190 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).