CMap Candidate Details

Structure:
CMap ID: C12173
Pert ID: BRD-K30867024
Compound Name: SB-216641
Targets: HTR1B; HTR1D
MoA: Serotonin receptor antagonist
SMILES: COc1ccc(NC(=O)c2ccc(cc2)-c2ccc(cc2C)-c2noc(C)n2)cc1OCCN(C)C
InchiKey: JRNUKVFYILMMLX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6177 BRD-K30867024 PC3 10 uM 24 h 0.0 0.0 0.0 0.4 1.4 2.18
6308 BRD-K30867024 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39112 BRD-K30867024 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39663 BRD-K30867024 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40783 BRD-K30867024 NEU 10 uM 24 h 0.23 0.98 0.09 -0.28 -0.93 0.34
41084 BRD-K30867024 NPC 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
41417 BRD-K30867024 SKB 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
82759 BRD-K30867024 A549 4 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
82850 BRD-K30867024 HA1E 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
82943 BRD-K30867024 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
83040 BRD-K30867024 HEPG2 4 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
83137 BRD-K30867024 HT29 10 uM 24 h 0.19 0.81 0.0 0.23 0.83 0.11
83223 BRD-K30867024 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99820 BRD-K30867024 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).