CMap Candidate Details

Structure:
CMap ID: C01223
Pert ID: BRD-A50998626
Compound Name: palomid-529
Targets: MTOR
MoA: Akt inhibitor; MTOR inhibitor; VEGFR inhibitor; Fibroblast growth factor inhibitor
SMILES: COc1ccc(COc2cc3oc(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1
InchiKey: YEAHTLOYHVWAKW-UHFFFAOYSA-N
Compound Aliases: PALOMID-529

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87312 BRD-A50998626 BJAB 0.125 uM 6 h -0.18 -0.76 0.0 0.0 0.0 0.0
87337 BRD-A50998626 HBL1 0.01 uM 24 h -0.17 -0.7 0.0 0.28 0.98 0.39
87385 BRD-A50998626 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87434 BRD-A50998626 KMS34 0.01 uM 24 h 0.18 0.76 0.0 0.35 1.25 1.29
87495 BRD-A50998626 MINO 0.01 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87537 BRD-A50998626 NALM6 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87587 BRD-A50998626 OCILY10 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
87639 BRD-A50998626 OCILY19 0.01 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
87687 BRD-A50998626 OCILY3 10 uM 24 h -0.3 -1.27 0.73 -0.29 -0.96 0.44
87738 BRD-A50998626 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87812 BRD-A50998626 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87860 BRD-A50998626 TMD8 0.66 uM 6 h 0.0 0.0 0.0 -0.37 -1.23 1.28
95301 BRD-A50998626 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95383 BRD-A50998626 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124567 BRD-A50998626 A375 10 uM 24 h 0.26 1.1 0.24 -0.36 -1.21 1.24
124606 BRD-A50998626 HA1E 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
124678 BRD-A50998626 HT29 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
124714 BRD-A50998626 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
124777 BRD-A50998626 MDAMB231 10 uM 24 h -0.22 -0.92 0.06 -0.26 -0.87 0.23
124823 BRD-A50998626 PC3 10 uM 24 h 0.27 1.13 0.28 -0.43 -1.44 15.35
132737 BRD-A50998626 HEK293 0.25 uM 24 h -0.25 -1.03 0.2 0.37 1.29 1.49
132779 BRD-A50998626 HELA 2.22 uM 24 h -0.2 -0.85 0.01 0.34 1.2 1.13
132854 BRD-A50998626 MCF10A 0.01 uM 24 h 0.21 0.88 0.01 0.31 1.11 0.72
132893 BRD-A50998626 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
132941 BRD-A50998626 YAPC 0.01 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).