CMap Candidate Details

Structure:
CMap ID: C12233
Pert ID: BRD-K31054881
Compound Name: BMY-7378
Targets: ADRA1D; ADRA1B; ADRA1A; HTR1A
MoA: Serotonin receptor antagonist; Adrenergic receptor antagonist
SMILES: COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
InchiKey: AYYCFGDXLUPJAQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4212 BRD-K31054881 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.74
4409 BRD-K31054881 HCC515 10 uM 24 h 0.0 0.0 0.0 0.19 0.67 0.01
4796 BRD-K31054881 PC3 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.2 1.17
5067 BRD-K31054881 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.48
39114 BRD-K31054881 A375 10 uM 6 h -0.21 -0.9 0.04 0.31 1.09 0.68
39315 BRD-K31054881 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
39665 BRD-K31054881 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39978 BRD-K31054881 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40254 BRD-K31054881 HT29 10 uM 6 h -0.21 -0.88 0.03 -0.27 -0.91 0.31
40608 BRD-K31054881 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40785 BRD-K31054881 NEU 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
41086 BRD-K31054881 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41419 BRD-K31054881 SKB 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
99822 BRD-K31054881 U2OS 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.12
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).