CMap Candidate Details

Structure:
CMap ID: C12250
Pert ID: BRD-K31111078
Compound Name: dimethyl-fumarate
Targets: NFE2L2; KEAP1
MoA: NRF2 activator; NFKB pathway inhibitor; Kelch-like ECH-associated protein ligand
SMILES: COC(=O)C=CC(=O)OC
InchiKey: LDCRTTXIJACKKU-ONEGZZNKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120507 BRD-K31111078 A375 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
120539 BRD-K31111078 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120585 BRD-K31111078 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120640 BRD-K31111078 HT29 10 uM 24 h 0.15 0.65 0.0 0.0 0.0 0.0
120690 BRD-K31111078 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120744 BRD-K31111078 MCF??7.00 10 uM 24 h 0.21 0.87 0.01 -0.26 -0.88 0.24
120764 BRD-K31111078 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120796 BRD-K31111078 YAPC 0.04 uM 24 h -0.21 -0.89 0.04 -0.25 -0.85 0.2
129018 BRD-K31111078 HELA 0.25 uM 24 h -0.25 -1.05 0.23 0.38 1.33 1.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).